FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

Read More..

Fiery Last-Lap Daytona Crash Injures 15 Fans

A fiery last-lap crash at the Daytona International Speedway injured a number of spectators today, who were seen being carried away from the stands on stretchers.

Fifteen spectators were taken to the hospital, according to ESPN, with one on the way to surgery with head trauma.

The 12-car crash happened moments before the end of the Nationwide race, and on the eve of the Daytona 500, one of NASCAR's biggest events.

The crash was apparently triggered when driver Regan Smith's car, which was being tailed by Brad Keselowski on his back bumper, spun to the right and shot up the track. Smith had been in the lead and said after the crash he had been trying to throw a "block."

Rookie Kyle Larson's car slammed into the wall that separates the track from the grandstands, causing his No. 32 car to go airborne and erupt in flames.

When a haze of smoke cleared and Larson's car came to a stop, he jumped out uninjured.

His engine and one of his wheels were sitting in a walkway of the grandstand.

"I was getting pushed from behind," Larson told ESPN. "Before I could react, it was too late."

Driver Michael Annett was taken to the hospital after he slammed head-on into a barrier during the chaos. NASCAR officials told ESPN the driver was awake and alert.

Tony Stewart pulled out the win, but in victory lane, what would have been a celebratory mood was tempered by concern for the injured fans.

"We've always known this is a dangerous sport," Stewart said. 'But it's hard when the fans get caught up in it."

Read More..

Berlusconi slams Europe's 'lords of austerity'

ROME: Italy's Silvio Berlusconi on Saturday said Europe's "lords of austerity" had tried to get rid of him, speaking in apparent breach of rules for candidates to stay silent the day before elections.

"I contradicted the lords of austerity who are now trying to get rid of me," Berlusconi was quoted by the ANSA news agency as saying in Milan in an interview with Greek television.

Leftist candidate Antonio Ingroia asked for sanctions against the billionaire tycoon but Berlusconi's office said the interview had been given only with the explicit agreement that it be released on Monday after polls close.

The comments were then widely quoted by Italian media.

In the interview, the scandal-tainted Berlusconi said outgoing prime minister Mario Monti was "subservient and always on his knees in front of Mrs Merkel (German Chancellor Angela Merkel) and now she does not want to lose him".

"The same thing would happen with (centre left leader and poll favourite Pier Luigi) Bersani. But I would give her a run for her money," he said.

"Austerity increases the public debt and lead to a recessionary spiral that pushes up unemployment and can result in the loss of social calm," he added.

Berlusconi, who is currently a defendant in two trials for tax fraud and for having sex with an underage prostitute, also said prosecutors were "a worse mafia than the Sicilian mafia".

Italians take to the polls on Sunday and Monday, Berlusconi expected to come a close second after Bersani.

- AFP/jc

Read More..

Stuck to rubber, terrorists let go of gun

AGARTALA: Ranjit Debbarma still remembers the day 11 years ago when, as an area commander with banned terrorist group NLFT, he trekked for two months -- from the Jampui hills to Rangamurra and then to border areas of Bangladesh before finally reaching Burma -- to carry back Ak 47, 56, M 16 and SK guns for the insurgency back home in Tripura.

Today, though, the 37-year-old can be seen going from one rubber tree to another, collecting latex and talking to his labourers in the plantation at Jarul Bachai, about 13 km from Agartala. His daughter is in an English school and he now wants to buy a motorbike so that it's easier for him to drop her to class every day.

"We were safe in the camps of both Bangladesh and Burma then," the National Liberation Front of Tripura guerrilla says, squinting under an unusually bright February sun. "But I now realize that we were misled. I spent six years of my life carrying arms and collecting protection money from terrified people. We were told Tripura should be for its indigenous people and that even our king has been dispossessed by the Bengalis who came here much after we did. We had taken this falsehood as religion. Rubber is the only thing that matters to me now, my only god."

Tripura's burgeoning rubber trade, which has grown from a cultivable area of just 3500 hectares in 1982 to a massive 57,620 hectares in 2012, has changed the life of Debbarma and hundreds of other former militants like him in Tripura. A senior Rubber Board official puts the number at 754. "I have personally trained 60 of them," he says. "This has been a major rehabilitation effort, and I would go to the extent of saying it helped curb insurgency. People like Debbarma will always be grateful to the CPM government for this, if nothing else."

A state done in by lack of connectivity with the rest of the country and an even greater absence of industry, Tripura has been quick to latch on to rubber, spreading fear in many that the way things are going no one will be cultivating anything else in the near future. "Now it is second only to Kerala in terms of production," says Madhu Chatterjee, who has around 100 kanis (6.25 kanis make a hectare) devoted to the crop. "More than 50,000 farmers are involved in this these days as the returns are very high - a kg goes for Rs 210 on an average and profits can be more than Rs 100 - and the state has just the kind of weather that suits this thing. Even those with very little money can invest in it."

A rubber board official, who doesn't want to be named, says that the government is still reluctant to come clean regarding the names or numbers of former rebels who have either been given money to invest in rubber or have been provided small patches of land. "Most of those who came for training used their nom de guerre and went away leaving behind their nom de guerre," he says, adding, "I think we are better off not knowing who they really were, how many they killed and how many lives they ruined. That was the quid pro quo - give us a new life and we'll leave you in peace."

Back in Debbarma's field, he says he knows at least ten others like him who are leading normal lives, stuck to latex, and working as farmers and plantation managers. "If every government helps terrorists in this way, few will pick up the gun,'' he says. "After all, it is only us poor who because of hunger and penury are easy targets for recruitment. You can brainwash easily a man with no food on his table."

Read More..

FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

Read More..

Jodi Arias' Friends Believe in Her Innocence

Accused murderer Jodi Arias believes she should be punished, but hopes she will not be sentenced to death, two of her closest friends told ABC News in an exclusive interview.

Ann Campbell and Donavan Bering have been a constant presence for Arias wth at least one of them sitting in the Phoenix, Ariz., courtroom along with Arias' family for almost every day of her murder trial. They befriended Arias after she first arrived in jail and believe in her innocence.

Arias admits killing her ex-boyfriend Travis Alexander and lying for nearly two years about it, but insists she killed Alexander in self defense. She could face the death penalty if convicted of murder.

Jodi Arias Testimony: Prosecution's Cross-Examination Watch Video

Jodi Arias Remains Calm Under Cross-Examination Watch Video

Jodi Arias Doesn't Remember Stabbing Ex-Boyfriend Watch Video

Nevertheless, she is aware of the seriousness of her lies and deceitful behavior.

The women told ABC News that they understand that Arias needs to be punished and Arias understands that too.

"She does know that, you know, she does need to pay for the crime," Campbell said. "But I don't want her to die, and I know that she has so much to give back."

Catching Up on the Trial? Check Out ABC News' Jodi Arias Trial Coverage

The lies that Arias admits she told to police and her family have been devastating to her, Bering said.

""She said to me, 'I wish I didn't have to have lied. That destroyed me,'" Donovan said earlier this week. "Because now when it's so important for her to be believed, she has that doubt. But as she told me on the phone yesterday, she goes, 'I have nothing to lose.' So all she can do is go out there and tell the truth."

During Arias' nine days on the stand she has described in detail the oral, anal and phone sex that she and Alexander allegedly engaged in, despite being Mormons and trying to practice chastity. She also spelled out in excruciating detail what she claimed was Alexander's growing demands for sex, loyalty and subservience along with an increasingly violent temper.

Besides her two friends, Arias' mother and sometimes her father have been sitting in the front row of the courtroom during the testimony. It's been humiliating, Bering said.

"She's horrified. There's not one ounce of her life that's not out there, that's not open to the public. She's ashamed," she said.

Read More..

Rockets hit Aleppo, killing at least 29: monitor

BEIRUT (Reuters) - Rockets struck eastern districts of Aleppo, Syria's biggest city, on Friday, killing at least 29 people and trapping a family of 10 in the ruins of their home, activists in the city said.

"There are families buried under the rubble," said an activist called Baraa al-Youssef, speaking by Skype after visiting the scene in his Ard al-Hamra neighborhood.

"Nothing can describe it, it's a horrible sight."

Video footage posted by several activists showed a burning building and people carrying the wounded to cars to be ferried to hospital. It was hard to gauge the scale of the damage in the night-time footage but rubble was clearly visible on the ground.

Rami Abdulrahman of the British-based Syrian Observatory for Human Rights said three explosions shook Aleppo and reported at least 29 people had been killed. Another 150 were wounded, he said, and the final death toll was likely to be higher.

Youssef said 30 houses were destroyed by a single rocket.

On Tuesday activists said at least 20 people were killed when a large missile of the same type as Russian-made Scuds hit the rebel-held district of Jabal Badro.

(Reporting by Mariam Karouny and Dominic Evans; Editing by Stephen Powell)

Read More..

Pope to quit Twitter after stepping down: Vatican Radio

VATICAN CITY: The pope's official Twitter account, which has more than two million followers in nine languages, will close next week when Benedict XVI leaves office, Vatican Radio said Friday.

After a high-profile launch on December 12 under the name @pontifex, the pontiff's online musings quickly attracted over 1.5 million followers in English. Around a million other users of the site subscribe to his feeds in Italian, Spanish, German, French, Portuguese, Polish, Arab and even Latin and a Chinese account had been planned.

"It seemed unimaginable one could continue to use a communication tool that is so popular and powerful during the Sede Vacante (Vacant Seat) period," Vatican Radio said.

The leader of the world's 1.2 billion Catholics is expected to post his final tweet on February 27, when he will bid a farewell to ordinary Catholics at a general audience in St Peter's Square.

The account will then be closed on February 28 when Benedict formally steps down as pope, according to Vatican Radio.

No clear favourite has emerged yet to succeed Benedict but several cardinals tipped as possible candidates, including American Timothy Dolan, Odilo Scherer from Brazil and Gianfranco Ravasi and Angelo Scola from Italy, who are active Twitter users within the Church.

Benedict's bold move to become the first pope to join the Twittersphere sparked heated debate at the Vatican and within the Church. Supporters said it was a useful way to reach a younger generation, but some observers were dismayed to see that his pious posts invited a stream of mockery.

- AFP/jc

Read More..

Hyderabad, hotbed of home-grown terror, under lens

NEW DELHI: For the veterans of security establishment the bomb blasts have revived concerns about the critical nature of Hyderabad and surroundings in the growth of home-grown terrorism in India.

Officials point out that Hyderabad has been intricately linked to the growth of the present phase of domestic terrorism. When the first definite information about Muslim youth going to Pakistan for terror camps emerged more than a decade ago, with Hyderabad resident Shahid Bilal as a key figure, the government was alarmed at the highest levels. Once India confirmed that over 60 youth have gone across to Pakistan from Andhra Pradesh and Karnataka in 2005-06 the issue was taken up with Bangladeshi and Nepalese governments because most of them were going via either of these countries.

"Even if the bombers are from outside, they have received local logistical support," says one official. "There is a history here," he says about Hyderabad's brush with blasts as well as with fringe sympathisers.

A day before the twin blasts, the National Investigation Agency (NIA) had, in fact, filed its first charge sheet in the case of Bangalore-Hubli-Nanded terror module run from Saudi Arabia by LeT-HuJI handlers. One name among the 12 accused stood out: Obaidur Rehman. The 26-year-old Hyderabad resident is the nephew of Maulana Mohammed Naseeruddin, a radical preacher presently languishing in a Gujarat jail in connection with the murder of Gujarat home minister Haren Pandya.

The charge sheet also mentioned the man handling the group from Saudi Arabia as Farhatullah Ghori, maternal uncle of slain HuJI operative Shahid Bilal. Both belong to Hyderabad.

The blasts that followed the charge sheet have only come as a grim reminder of the Andhra Pradesh capital having become a favourite recruiting ground for terror groups. In fact, the city has been in terror crosshairs for close to a decade and a half providing strong base to both LeT and HuJI.

According to intelligence agencies, Hyderabad first came on terror radar in late '90s with several radical religious organizations becoming a springboard to youth taking to terror. While there was an entrenched sense of victimhood and injustice post Babri masjid demolition among Muslims in the state, their anger was first organized and harnessed by Mohammed Abdul Shahid alias Shahid Bilal under aegis of HuJI.

The first effects of this endeavor manifested itself in the terror attack on the office of Hyderabad Special Task Force in 2003. Bilal's maternal uncle Farhatullah Ghori's name prominently cropped up in the investigations. He was also a suspect in the Akshardham Temple attack in Gujarat in 2002.

Following this, Bilal was found to be instrumental in conducting several blasts across south India between 2004 and 2007. During this period he also helped 26/11 accused and LeT operative Zabiuddin Ansari alias Abu Jundal escape to Pakistan via Bangladesh along with his associate Fayyaz Kagzi after the 2006 Aurangabad arms haul in Maharashtra. In October 2007, Bilal was himself killed in Karachi along with his brother Samad. However, sources say, he has five more brothers who are in Pakistan and elsewhere. And the network he has left behind across India, Pakistan and Saudi Arabia keeps recruiting people for Jihadi activities.

In 2008, Maulana Naseeruddin's son, Riyazuddin Nasir, was arrested in Dharwad, Karnataka for planning to carry out terror strikes in the state. In 2012, with Obaidur Rehman's arrest in the Bangalore terror module, the city again struggled to shake off the terror tag.

Read More..

APNewsBreak: Governors to hear health care plan

SALEM, Ore. (AP) — Gov. John Kitzhaber will pitch his overhaul of Oregon's Medicaid system to other governors in a private session in Washington this weekend.

Kitzhaber says he's hoping to get a handful of governors from each party on board. He wants to make a bipartisan push to change the way doctors are paid and patients are treated.

The governor has been talking for two years about expanding his health care initiative beyond Oregon, and his effort may be picking up steam.

President Barack Obama highlighted the concept in his State of the Union as a potential deficit-reducing option for Medicare. The U.S. Department of Health and Human Services announced Thursday it's giving Oregon a $45 million grant help spread the changes beyond the Medicaid population and share information with other states.

Read More..

Las Vegas Shooting Launches Multi-State Manhunt

An argument in the valet area of a Las Vegas hotel led to a deadly drive-by shooting on the occupants of a Maserati on Vegas' glitzy strip, initiating a multi-state manhunt for the black Range Rover from which the shots were fired.

Three people were left dead in the attack, including two who died when their taxi was struck by the careening sports car and exploded into flames.

"What happened is not just tragic, but underscores the level of violence we see sometimes here in Las Vegas as well as across America," Las Vegas Metropolitan Sheriff Doug Gillespie said at a news conference today. "Clearly, the suspects in this shooting have no regard for the lives and safety of others."

The altercation took place in the valet area of the Aria resort and casino. Gillespie said there is currently "no indication" what the squabble was about.

Gillespie said that authorities do not know how many people are in the SUV, but that they are considered armed and dangerous. He warned members of the public to stay away from it.

"You should not take action," he said. "Instead, call your local police department and alert them to the whereabouts of the suspect vehicle."

Authorities in Nevada, Utah, Arizona and California are all on alert for the car.

"These individuals will be found," Gillespie said. "They will be prosecuted to the full extent of the law."

Steve Marcus/Las Vegas Sun/AP Photo

California Man's Carjacking Spree Takes 3 Victims Watch Video

Chicago Teen Killed Day of Obama's Anti-Violence Speech Watch Video

Dallas Courthouse Shooting Manhunt Intensify Watch Video

The Range Rover SUV shot at two people in the Maserati, which caused a multi-car crash. Police have not released the model of the Maserati, but the price of a new Maserati ranges from $123,000 to $142,000.

Police said that they believe a group of men riding in a black Range Rover Sport SUV pulled up alongside the Maserati around 4:20 a.m. today and fired shots into the car, striking the driver and passenger, according to Officer Jose Hernandez of the Las Vegas Metropolitan police department.

The Maserati then swerved through an intersection, hitting at least four other cars. One car that was struck, a taxi with a driver and passenger in it, caught on fire and burst into flames, trapping both occupants, Hernandez said.

The SUV then fled the scene, according to cops.

Gillespie said investigators are in the process of gathering video footage from hotels, casinos and the taxi cabs that were at the intersection.

The driver of the Maserati died from his gunshot wounds at University Medical Center shortly after the shooting, according to Sgt. John Sheahan.

The driver and passenger of the taxi both died in the car fire.

At least three individuals, including the passenger of the Maserati, were injured during the shooting and car crashes and taken to UMC hospital for treatment.

Authorities said the Maserati passenger, identified only as a man, sustained only a minor injury to his arm. He is speaking to and cooperating with police.

They do not yet know whether the cars had local plates or were from out of state.

No bystanders were hit by gunfire, Hernandez said.

"We're currently looking for a black Range Rover Sport, with large black rims and some sort of dealership advertising or advertisement plates," Hernandez said. "This is an armed and dangerous vehicle."

The Las Vegas Convention and Visitors Authority had no immediate comment about the safety of tourists in the wake of the shooting today.

Read More..

Football: Laudrup tells Swansea to take initiative in final

LONDON: Swansea City coach Michael Laudrup said his side should have no concerns about being branded favourites ahead of their meeting with fourth-tier Bradford City in Sunday's English League Cup final.

Swansea will be appearing in their first major cup final, but their achievement pales in comparison to that of Bradford, who have eliminated three Premier League sides en route to Wembley Stadium.

League Two Bradford are the first team from the English fourth division to reach the League Cup final since Rochdale in 1962 and Laudrup said Swansea must be prepared to shake off their own underdog mindset as a result.

"I would think if you go back, it's very rare to see a major final between a small team in the top flight and a team from the lower leagues," said the Dane.

"When teams from lower down get to the final, it is normally against Manchester United, Manchester City, Chelsea, Arsenal, Tottenham or Liverpool -- like when Birmingham played Arsenal (in 2011).

"This is different because although we are one of the lower teams, we have to accept we are favourites and we must take the initiative in the game.

"We have no problem with that and we accept the majority of people will want Bradford to win as they are the underdogs.

"We have seen what they have done to Wigan, Arsenal and especially to Aston Villa over two legs.

"It is fantastic. If you say what we have done is a fairytale, then the fact Bradford are there is a huge fairytale."

Laudrup also confirmed that Spanish centre-back Chico Flores will not be available to play at Wembley after he ruptured ankle ligaments in the 4-1 league win over Queens Park Rangers on February 9.

"Chico tried today (Thursday) to go out and train, but it was much too early, we all knew that," said Laudrup.

"It is an injury you would normally estimate to be out for four to eight weeks and this Saturday would be two weeks.

"It is such an important game, but today he realised it is much too soon and he has to accept the fact."

In Flores' absence, Kyle Bartley and club captain Garry Monk will vie for the right to partner Ashley Williams in central defence.

Laudrup also revealed that German second-choice goalkeeper Gerhard Tremmel will continue between the posts, having been preferred to first-choice custodian Michel Vorm in Swansea's previous games in the competition.

- AFP/fa

Read More..

British intel had warned of Indian Mujahideen attack

NEW DELHI: The British intelligence had warned India about a possible terrorist attack by the homegrown terror outfit, Indian Mujahideen (IM). The alert led to a general nationwide alert on Wednesday.

The British intelligence alert is believed to have been received by Indian agencies just as British PM David Cameron was about to land in Mumbai on Monday. The input did not speak of any specific movements of terrorists or any particular module. Sources said it may have been based on inputs gathered by the heightened British intelligence gathering in the region ahead of Cameron's visit.

On Wednesday, a general alert was issued by the Intelligence Bureau (IB) about a possible attack by the IM. The alert was based on the British input, and came after several weeks of silence about any IM activity.

There are no dependable inputs with agencies until now about any IM module being active of late, sources said. However, investigations of recent times have indicated that the entire network of the homegrown terror group may not have been unearthed.

The IM tentacles are not just limited to some Indian cities, but it also has very strong affiliations among the Indian diaspora. The activities of IM are believed to have regular funding from West Asian countries. Also, some of the first Indian terrorists to have emerged in the communally vicious times of the 1990s — mostly having undergone terror training in Pakistan — are now based in the Gulf region. Among them is C A M Basheer, a former senior SIMI leader.

Read More..

Agency checks water after body found in hotel tank

LOS ANGELES (AP) — British tourist Michael Baugh and his wife said water had only dribbled out of the taps at the downtown Cecil Hotel for days.

On Tuesday, after showering, brushing their teeth and drinking some of the tap water, they headed down to the lobby and found out why.

The body of a Canadian woman had been discovered at the bottom of one of four cisterns on the roof of the historic hotel near Skid Row. The tanks provide water for hotel taps and would have been used by guests for washing and drinking.

"The moment we found out, we felt a bit sick to the stomach, quite literally, especially having drank the water, we're not well mentally," Michael Baugh, 27, said.

Los Angeles County Department of Public Health officials issued a do-not-drink order Tuesday while its lab analyzes the water, said Allen Solomon, a spokesman for the department. The disclosure contradicts a previous police statement that the water had been deemed safe.

Solomon said the water was also used for cooking in the hotel. Results of the testing were expected Thursday.

A call to the hotel was not returned.

The remains of Elisa Lam, 21, were found by a maintenance worker at the 600-room hotel that charges $65 a night after guests complained about the low water pressure.

Police detectives were working to determine if her death was the result of foul play or an accident.

Lopez called it suspicious and said a coroner's investigation will determine Lam's cause of death.

Before she died, hotel surveillance footage showed Lam inside an elevator pushing buttons and sticking her head out the doors, looking in both directions. She was later found in the water tank.

The discovery turned the Baughs' two-week vacation into a nightmare.

"We'd hop in the shower, imagine, the water sprinkles out, and this is the only appropriate word, it dribbled out," Baugh said.

He and his wife Sabina, 27, who were on their first trip to the U.S., had booked their room as part of a tour package and had "no idea that it was in a dodgy area," he said.

The hotel is on Main Street in a part of downtown where efforts at gentrification often conflicts with homelessness and crime.

"When you look at the area, it's not surprising," Baugh said of the discovery of the body. "Everyone we spoke to said why are you staying there? Don't walk at night in that area, stay indoors."

Lam, of Vancouver, British Columbia, traveled alone to Los Angeles on Jan. 26 and was last seen five days later by workers at the hotel.

Lopez said the hotel has four cisterns on its roof that are each about 10 feet tall, 4.5 feet wide and hold at least 1,000 gallons of water.

Lam's body was found Tuesday morning at the bottom of one cistern that was about three-quarters full of water, Lopez said.

The opening at the top of the cistern is too small to accommodate firefighters and equipment, so they had to cut a hole in the storage tank to recover Lam's body.

The cisterns are on a platform at least 10 feet above the roof.

To get to the tanks, someone would have to go to the top floor then take a staircase with a locked door and emergency alarm preventing roof access.

Another ladder would have to be taken to the platform and a person would have to climb the side of the tank.

Lopez said there are no security cameras on the roof.

Lam intended to travel to Santa Cruz, about 350 miles north of Los Angeles. Officials said she tended to use public transportation and had been in touch with her family daily until she disappeared.

The Cecil Hotel was built in the 1920s and refurbished several years ago. It had once been the occasional home of infamous serial killers such as Richard Ramirez, known as the Night Stalker, and Austrian prison author Jack Unterweger, who was convicted of murdering nine prostitutes in Europe and the U.S., the Los Angeles Times reported.

Baugh and his wife had planned to go to SeaWorld on Wednesday but instead camped in the hotel lobby for more than 12 hours because they refused to sign a health risk waiver to stay in their rooms as they waited to hear back from their tour agency to be placed elsewhere.

"We've got nowhere to go, we've got all our luggage with us," Michael Baugh said.

They also called their family and the British Embassy trying to figure out what to do.

The couple hadn't touched any water at the hotel since learning the body had been discovered.

Eventually, they were placed at another downtown hotel with a less than sterling reputation, from what they heard.

"We're just going from one dodgy place to another," Baugh said, resigned, "but at least there's water."

___

Tami Abdollah can be reached at http://www.twitter.com/latams. Shaya Tayefe Mohajer contributed to this report.

Read More..

Armstrong Snubs Offer From Anti-Doping Officials

Lance Armstrong has turned down what may be his last chance at reducing his lifetime sporting ban.

Armstrong has already admitted in an interview with Oprah Winfrey to a career fueled by doping and deceit. But to get a break from the U.S. Anti-Doping Agency, all he had to do was tell his story to those who police sports doping. The deadline was today, and Armstrong now says he won't do it.

"For several reasons, Lance will not participate in USADA's efforts to selectively conduct American prosecutions that only demonize selected individuals while failing to address the 95 percent of the sport over which USADA has no jurisdiction," said Tim Herman, Armstrong's longtime lawyer. "Lance is willing to cooperate fully and has been very clear: He will be the first man through the door, and once inside will answer every question, at an international tribunal formed to comprehensively address pro cycling."

But the "international tribunal" Armstrong is anxious to cooperate with has one major problem: It doesn't exist.

The UCI, cycling's governing body, has talked about forming a "truth and reconciliation" commission, but the World Anti-Doping Agency has resisted, citing serious concerns about the UCI and its leadership.

READ MORE: Armstrong Admits to Doping

Livestrong, Elizabeth Kreutz/AP Photo

READ MORE: Lance Armstrong May Have Lied to Winfrey: Investigators

WATCH: Armstrong's Many Denials Caught on Tape

U.S. Anti-Doping Agency officials seemed stunned by Armstrong's decision simply to walk away.

"Over the last few weeks, he [Armstrong] has led us to believe that he wanted to come in and assist USADA, but was worried of potential criminal and civil liability if he did so," said Travis Tygart, CEO of the U.S. Anti-Doping Agency. "Today, we learned from the media that Mr. Armstrong is choosing not to come in and be truthful and that he will not take the opportunity to work toward righting his wrongs in sport."

Armstrong's ongoing saga plays out amid a backdrop of serious legal problems.

Sources believe one reason Armstrong wants to testify to an international tribunal, rather than USADA, is because perjury charges don't apply if Armstrong lies to a foreign agency, they told ABC News.

While Armstrong has admitted doping, he has not given up any details, including the people and methods required to pull off one of the greatest scandals in all of sport.

Armstrong is facing several multimillion-dollar lawsuits right now, but his biggest problems may be on the horizon. As ABC News first reported, a high-level source said a criminal investigation is ongoing. And the Department of Justice also reportedly is considering joining a whistleblower lawsuit claiming the U.S. Postal Service was defrauded out of millions of dollars paid to sponsor Armstrong's cycling team.

READ MORE: 10 Scandalous Public Confessions

PHOTOS: Olympic Doping Scandals: Past and Present

Read More..

French general urges EU to equip "impoverished" Mali army

BAMAKO, Mali (Reuters) - The European Union should complement a mission to train Mali's army, routed by rebels last year, by providing equipment from uniforms to vehicles and communications technology, a French general said on Wednesday.

General Francois Lecointre, appointed to head the EU training mission to Mali (EUTM) that was formally launched this week, said in Bamako equipping the "very impoverished" and disorganized Malian army was as important as training it.

Europe, along with the United States, has backed the French-led military intervention in Mali which since January 11 has driven al Qaeda-allied Islamist insurgents out of the main northern towns into remote mountains near Algeria's border.

European governments have ruled out sending combat troops to join French and African soldiers pursuing the Islamist rebels.

But the EU is providing a 500-strong multinational training force that will give military instruction to Malian soldiers for an initial period of 15 months at an estimated cost of 12.3 million euros ($16.45 million).

While hailing what he called the EU's "courageous, novel, historic" decision to support Mali, Lecointre told a news conference the Malian army's lack of equipment was a problem.

"I know the Malian state is poor, but the Malian army is more than poor," the French general told a news conference, adding that it urgently needed everything from uniforms and weapons to vehicles and communications equipment.

Last year, when Tuareg separatist forces swelled by weapons and fighters from the Libyan conflict swept out of the northern deserts, a demoralized and poorly-led Malian army collapsed and fled before them, abandoning arms and vehicles.

Mali's military was further shaken by a March 22 coup by junior officers who toppled President Amadou Toumani Toure, sowing division among rival army factions. Islamist radicals allied to al Qaeda later hijacked the victorious Tuareg rebellion to occupy the northern half of the country.

In a fast-charging military campaign led by Paris, French and African troops have driven the jihadists out of principal northern towns like Gao and Timbuktu, and are fighting the rebels in the Adrar des Ifoghas mountains.

HUMAN RIGHTS INSTRUCTION

Flanked by Mali's armed forces chief, General Ibrahima Dembele, Lecointre said he was disappointed that a meeting of international donors last month pledged funds for an African military force, known as AFISMA, being deployed in Mali, but included "very few" contributions for the Malian army itself.

"The European Union needs to invest today in the equipping of the Malian army and not just in its training," the general said, adding he would make this point strongly in a report to EU member state representatives early next month.

Asked how much re-equipping the army would cost, he said it would be "much more" than the 12 million euros of EU financing for the training mission, but could not give a precise estimate.

Starting early in April, the EU mission will start instructing Malian soldiers with a plan to train four new battalions of 600-700 members each, formed from existing enlisted men and new recruits.

Lecointre said the EU training would include instruction in human rights. Demands for this increased after allegations by Malian civilians and international human rights groups that Malian soldiers were executing Tuaregs and Arabs accused of collaborating with Islamist rebels.

The European training contingent is drawn from a range of European countries, but the main contributors would be France, Germany, Italy, Spain and Britain, EUTM officers said.

Mali's army has received foreign training before - several battalions that fled before the rebels last year were trained by the U.S. military and the leader of the March 22 coup, Captain Amadou Sanogo, attended training courses in the United States.

Dembele said U.S. training failed to forge cohesion among Malian units and he hoped the EU training would achieve this.

The United States, which halted direct support for the Malian military after last year's coup, could eventually resume aid if planned national elections in July fully restore democracy to the West African country.

Washington is providing airlift, refuelling and intelligence support to the French-led military intervention in Mali. ($1 = 0.7479 euros)

(Reporting by Pascal Fletcher; Editing by Jason Webb)

Read More..

US stocks dive after Fed minutes

NEW YORK: US stocks piled up losses Wednesday after Federal Reserve minutes showed divisions over asset purchases, with some officials suggesting to wind them down before the jobs market picks up.

The Dow Jones Industrial Average finished down 108.13 points (0.77 percent) at 13,927.54.

The S&P 500-stock index fell 18.99 points (1.24 percent) to 1,511.95 and the tech-rich Nasdaq Composite dropped 49.18 points (1.53 percent) to 3,164.41, dragged down by heavyweight Apple, off 2.4 percent.

After opening mostly lower amid mixed housing and wholesale inflation data, the indexes hit fresh session lows after the Fed released the minutes of the January 29-30 Federal Open Market Committee meeting.

A "number" of participants said that an ongoing evaluation of the $85 billion per month asset purchases "might well lead the committee to taper or end its purchases before it judged that a substantial improvement in the outlook for the labor market had occurred," the minutes said.

Paul Edelstein of IHS Global Insight said in a research note that "if markets do not expect the Fed to stay the course, then expectations for economic growth and inflation will stay depressed and demand for safe assets (cash and government securities) will remain high."

Office Depot and OfficeMax meanwhile confirmed their merger after a premature announcement of the news.

The all-stock merger would create an $18 billion office supplies retailer. Office Depot shares slumped 16.7 percent and OfficeMax shed 7.0 percent.

Hotel chain Marriott fell 2.7 percent after posting quarterly results that missed expectations.

Luxury home builder Toll Brothers also suffered from disappointing earnings, losing 9.1 percent.

Dell, which reported a 32 percent profit fall in 2012 that was nevertheless slightly better than expected, rose 0.2 percent.

Yahoo! fell 1.7 percent after unveiling a new homepage.

Sony slid 1.2 percent ahead of its PlayStation 4 news conference

The bond market was mixed. The yield on the 10-year Treasury bond fell to 2.02 percent from 2.03 percent late Tuesday, while the 30-year edged up to 3.21 percent from 3.20 percent. Bond prices and yields move inversely.

-AFP/ac

Read More..

West Bengal govt plans to depoliticize students' union polls

KOLKATA: Increasing incidence of violence on campuses in West Bengal has forced the Mamata Banerjee government to explore ways to depoliticise students' union elections. The state education department has drawn up a draft guideline that proposes to delink student bodies from political parties and make college union polls a 'once-in-two-years' event.

Education minister Bratya Basu is expected to submit the draft to chief minister Mamata Banerjee early next week. "Only after the chief minister's go-ahead, a final draft will be prepared and placed before the cabinet for approval," Basu told TOI on Wednesday.

The proposal comes barely a week after a policeman was shot dead during clashes between students' groups in a city college.

Calcutta University vice-chancellor Suranjan Das, higher education council chairman Sugata Marjit and the education minister have put their heads together to draw up the draft which will be put on the higher education department website on Thursday for stakeholders to give their suggestions.

The guidelines loosely follow the model of Bengal Engineering and Science University (Besu) where the student union has been replaced by a senate with several associate societies or clubs. The move has gone a long way in calming the restive Besu campus.

The latest move has been welcomed by academics. "This is an excellent attempt by the education minister. All my life, I have tried to propagate the idea to delink college politics from party politics. This is a move in the right direction. Now, the question is to implement the draft proposals," said former principal of Presidency College Amal Mukhopadhyay.

According to the draft, college elections will not be fought on political symbols. The student union will be renamed student council and its president will be nominated by the senior most teacher of the college. The vice-president will be nominated by the teachers' council. In case of universities, the vice-chancellor will select the president. The two vice-presidents will be nominated by the executive council and the court - the two top bodies in university administration.

The draft provides for election to the post of general secretary, assistant general secretary and five other secretaries who would look after student activities such as culture, drama, sports, etc. All students would either vote to elect these representatives as in the case of Jawaharlal Nehru University or Jadavpur University or the general secretary would be elected from among class representatives as is done in Calcutta University.

In keeping with the recommendations of the Lyngdoh Commission, an election observer will oversee the process and complete it within a month. The observer may wind up the entire process within 15 days, if he deems it fit.

Primacy has been given to the elected representatives. The elected general secretary will represent students in the college governing body while the general secretary of the students' council will make way to the university's highest body - the executive council.

The purpose is to integrate the students' bodies in the overall academic system rather than turning them into power centres of political parties.

Trinamool Congress Chhatra Parishad leader Shanku Deb Panda, however, reacted cautiously to the move. "We will have to see how far the guidelines can be implemented," he said.

"I have already sent the draft of the students' senate in Besu to the committee formed by the state government and our ideas have been appreciated. We will now wait to read the draft as prepared by the higher education department," said Ajay Ray, vice-chancellor of Besu.

Read More..

Drug overdose deaths up for 11th consecutive year

CHICAGO (AP) — Drug overdose deaths rose for the 11th straight year, federal data show, and most of them were accidents involving addictive painkillers despite growing attention to risks from these medicines.

"The big picture is that this is a big problem that has gotten much worse quickly," said Dr. Thomas Frieden, head of the Centers for Disease Control and Prevention, which gathered and analyzed the data.

In 2010, the CDC reported, there were 38,329 drug overdose deaths nationwide. Medicines, mostly prescription drugs, were involved in nearly 60 percent of overdose deaths that year, overshadowing deaths from illicit narcotics.

The report appears in Tuesday's Journal of the American Medical Association.

It details which drugs were at play in most of the fatalities. As in previous recent years, opioid drugs — which include OxyContin and Vicodin — were the biggest problem, contributing to 3 out of 4 medication overdose deaths.

Frieden said many doctors and patients don't realize how addictive these drugs can be, and that they're too often prescribed for pain that can be managed with less risky drugs.

They're useful for cancer, "but if you've got terrible back pain or terrible migraines," using these addictive drugs can be dangerous, he said.

Medication-related deaths accounted for 22,134 of the drug overdose deaths in 2010.

Anti-anxiety drugs including Valium were among common causes of medication-related deaths, involved in almost 30 percent of them. Among the medication-related deaths, 17 percent were suicides.

The report's data came from death certificates, which aren't always clear on whether a death was a suicide or a tragic attempt at getting high. But it does seem like most serious painkiller overdoses were accidental, said Dr. Rich Zane, chair of emergency medicine at the University of Colorado School of Medicine.

The study's findings are no surprise, he added. "The results are consistent with what we experience" in ERs, he said, adding that the statistics no doubt have gotten worse since 2010.

Some experts believe these deaths will level off. "Right now, there's a general belief that because these are pharmaceutical drugs, they're safer than street drugs like heroin," said Don Des Jarlais, director of the chemical dependency institute at New York City's Beth Israel Medical Center.

"But at some point, people using these drugs are going to become more aware of the dangers," he said.

Frieden said the data show a need for more prescription drug monitoring programs at the state level, and more laws shutting down "pill mills" — doctor offices and pharmacies that over-prescribe addictive medicines.

Last month, a federal panel of drug safety specialists recommended that Vicodin and dozens of other medicines be subjected to the same restrictions as other narcotic drugs like oxycodone and morphine. Meanwhile, more and more hospitals have been establishing tougher restrictions on painkiller prescriptions and refills.

One example: The University of Colorado Hospital in Aurora is considering a rule that would ban emergency doctors from prescribing more medicine for patients who say they lost their pain meds, Zane said.

___

Stobbe reported from Atlanta.

___

Online:

JAMA: http://www.jama.ama-assn.org

CDC: http://www.cdc.gov

___

AP Medical Writer Lindsey Tanner can be reached at http://www.twitter.com

Read More..

Report Fingers Chinese Military Unit in US Hacks

A Virginia-based cyber security firm has released a new report alleging a specific Chinese military unit is likely behind one of the largest cyber espionage and attack campaigns aimed at American infrastructure and corporations.

In the report, released today by Mandiant, China's Unit 61398 is blamed for stealing "hundreds of terabytes of data from at least 141 organizations" since 2006, including 115 targets in the U.S. Twenty different industrial sectors were targeted in the attacks, Mandiant said, from energy and aerospace to transportation and financial institutions.

Mandiant believes it has tracked Unit 61398 to a 12-story office building in Shanghai that could employ hundreds of workers.

"Once [Unit 61398] has established access [to a target network], they periodically revisit the victim's network over several months or years and steal broad categories of intellectual property, including technology blueprints, proprietary manufacturing processes, test results, business plans, pricing documents, partnership agreements, and emails and contact lists from victim organizations' leadership," the report says.

The New York Times, which first reported on the Mandiant paper Monday, said digital forensic evidence presented by Mandiant pointing to the 12-story Shangai building as the likely source of the attacks has been confirmed by American intelligence officials. Mandiant was the firm that The Times said helped them investigate and eventually repel cyber attacks on their own systems in China last month.

Peter Parks/AFP/Getty Images

The Chinese government has repeatedly denied involvement in cyber intrusions and Chinese Foreign Ministry spokesperson Hong Lei said today that the claims in the Mandiant report were unsupported, according to a report by The Associated Press.

"To make groundless accusations based on some rough material is neither responsible nor professional," he reportedly said.

Mandiant's report was released a week after President Obama said in his State of the Union address that America must "face the rapidly growing threat from cyber attack."

"We know hackers steal people's identities and infiltrate private e-mail. We know foreign countries and companies swipe our corporate secrets. Now our enemies are also seeking the ability to sabotage our power grid, our financial institutions, and our air traffic control systems. We cannot look back years from now and wonder why we did nothing in the face of real threats to our security and our economy," he said.

Though Obama did not reference China or any country specifically, U.S. officials have previously accused the Asian nation of undertaking a widespread cyber espionage campaign.

Referring to alleged Chinese hacking in October 2011, House Intelligence Committee Chairman Rep. Mike Rogers (R-Mich.) said in an open committee meeting that he did not believe "that there is a precedent in history for such a massive and sustained intelligence effort by a government agency to blatantly steal commercial data and intellectual property."

Rogers said that cyber intrusions into American and other Western corporations by hackers working on behalf of Beijing -- allegedly including attacks on corporate giants like Google and Lockheed Martin -- amounted to "brazen and widespread theft."

"The Chinese have proven very, very good at hacking their way into very large American companies that spend a lot of money trying to protect themselves," cyber security expert and ABC News consultant Richard Clarke said in an interview last week.

Read More..

Syria "Scud-type" missile said to kill 20 in Aleppo

AMMAN (Reuters) - A Syrian missile killed at least 20 people in a rebel-held district of Aleppo on Tuesday, opposition activists said, as the army turns to longer-range weapons after losing bases in the country's second-largest city.

The use of what opposition activists said was a large missile of the same type as Russian-made Scuds against an Aleppo residential district came after rebels overran army bases over the past two months from which troops had fired artillery.

As the uprising against President Bashar al-Assad, now a civil war, nears its two-year mark, rebels also landed three mortar bombs in the rarely-used presidential palace compound in the capital Damascus, opposition activists said on Tuesday.

The United Nations estimates 70,000 people have been killed in the conflict between largely Sunni Muslim rebels and Assad's supporters among his minority Alawite sect. An international diplomatic deadlock has prevented intervention, as the war worsens sectarian tensions throughout the Middle East.

A Russian official said on Tuesday that Moscow, which is a long-time ally of Damascus, would not immediately back U.N. investigators' calls for some Syrian leaders to face the International Criminal Court for war crimes.

Moscow has blocked three U.N. Security Council resolutions that would have increased pressure on Assad.

Casualties are not only being caused directly by fighting, but also by disruption to infrastructure and Syria's economy.

An estimated 2,500 people in a rebel-held area of northeastern Deir al-Zor province have been infected with typhoid, which causes diarrhea and can be fatal, due to drinking contaminated water from the Euphrates River, the World Health Organization (WHO) said on Tuesday.

"There is not enough fuel or electricity to run the pumps so people drink water from the Euphrates which is contaminated, probably with sewage," the WHO representative in Syria, Elisabeth Hoff, told Reuters by telephone.

The WHO had no confirmed reports of deaths so far.

BURIED UNDER RUBBLE

In northern Aleppo, opposition activists said 25 people were missing under rubble of three buildings hit by a several-meter-long missile. They said remains of the weapon showed it to be a Scud-type missile of the type government forces increasingly use in Aleppo and in Deir a-Zor.

NATO said in December Assad's forces fired Scud-type missiles. It did not specify where they landed but said their deployment was an act of desperation.

Bodies were being gradually dug up, Mohammad Nour, an activist, said by phone from Aleppo.

"Some, including children, have died in hospitals," he said.

Video footage showed dozens of people scouring for victims and inspecting damage. A body was pulled from under collapsed concrete. At a nearby hospital, a baby said to have been dug out from wreckage was shown dying in the hands of doctors.

Reuters could not independently verify the reports.

Opposition activists also reported fighting near the town of Nabak on the Damascus-Homs highway, another route vital for supplying forces in the capital loyal to Assad, whose family has ruled Syria since the 1960s.

Rebels moved anti-aircraft guns into the eastern Damascus district of Jobar, adjacent to the city centre, as they seek to secure recent gains, an activist said.

"The rebels moved truck-mounted anti-aircraft guns to Jobar and are now firing at warplanes rocketing the district," said Damascus activist Moaz al-Shami.

Russian Deputy Foreign Minister Gennady Gatilov told a news conference a U.N. war crimes report, which accuses military leaders and rebels of terrorizing civilians, was "not the path we should follow ... at this stage it would be untimely and unconstructive."

Syria is not party to the Rome Statute that established the ICC and the only way the court can investigate the situation is if it receives a referral from the Security Council, where Moscow is a permanent member.

(Writing by Oliver Holmes; Editing by Jason Webb)

Read More..

Google shares top $800 despite Microsoft challenge

NEW YORK: Internet search king Google's shares pushed past $800 for the first time Tuesday despite a tough new challenge from Microsoft and looming European Union action over alleged privacy violations.

Google's closed at $806.85 on the Nasdaq exchange, up 1.8 percent from Friday's close, after having hit $807 during the day.

That pushed the company's market valuation to $266 billion. The shares were up 14 percent from the beginning of 2013 and 33 percent over the past 52 weeks.

On January 22, Google reported firm 2012 fourth-quarter gains, with profit up 6.7 percent from a year earlier at $2.89 billion. For the full year, Google's earnings grew 10 percent to $10.74 billion, on revenues topping $50 billion.

Several analysts strengthened their recommendations for the shares with price targets ranging from $800 to $900, the latter from Cantor Fitzgerald.

But the company faces fresh challenges.

In a new push for its Outlook email service, Microsoft has launched a negative ad campaign against Google, asking readers if they have been "Scroogled" by Google's use of personal data from users of its Gmail service.

"Think Google respects your privacy? Think again," the Microsoft ads say.

"Google goes through every Gmail that's sent or received, looking for keywords so they can target Gmail users with paid ads."

Microsoft says its Outlook service will not scan emails to target online ads.

On Monday France's CNIL data protection agency said that European data privacy regulators intend to take action against Google after it failed to follow their orders to comply with EU privacy laws.

"At the end of a four-month delay accorded to Google to comply with the European data protection directive and to implement effectively (our) recommendations, no answer has been given," said CNIL.

National authorities responsible for enforcing data protection laws in the EU said they plan to set up a working group to "coordinate their coercive actions which should be implemented before the summer."

-AFP/ac

Read More..

No trace of 3,772 children missing from Delhi in last 5 years

NEW DELHI: Over 3,700 children, majority of whom are girls, went missing from Delhi homes in the last five years and are still untraceable yet the Delhi government says it has no evidence of organized gangs operating in the national capital indulging in kidnapping or trafficking of children.

The Delhi home department through advocate S Wasim Qadri cited a special initiative taken by Delhi Police under 'Pehchan' scheme to photograph children belonging to poorer sections of society living in slums.

"This scheme covers areas from where most children go missing and the police are unable to make any headway in tracing them as poor families seldom have photographs of their children. Delhi Police has so far photographed 64,755 children in the last last months," it said.

But the National Human Rights Commission was sceptical about the intent of state governments in protecting children from being kidnapped or trafficked. NHRC's affidavit filed through advocate Shobha said the states had confined to paper the guidelines for protection of children and went through the motion of filing periodic data before the commission.

On Tuesday, this made a bench of Chief Justice Altamas Kabir and Justices A R Dave and Vikramjit Sen to observe, "We are dealing with a PIL concerning children, who constitute 42% of the population. But this does not seem to bother the states which are supposed to be their guardians. This is possibly because they do not have voice."

Though the Delhi government listed its initiatives, it was discernible that the number of missing children not being traced in the last five years had registered a steady increase. Another disturbing factor in the statistics was that majority of the untraced children were girls.

In 2008, a total of 413 missing children remained untraceable of which 222 were girls. Corresponding figures in the next four years are - 485 untraceable of which 213 were girls (2009), 854 of which 416 were girls (2010), 981 of which 559 were girls (2011) and 1,139 of which 623 were girls (2012).

The Sheila Dikshit government said it was pro-active in analyzing the trends in kidnapping or missing children. "Involvement of organized gangs in kidnapping or trafficking of children for any unlawful activity has so far not come to notice in Delhi," it said.

On the other hand, the NHRC was scathing in its affidavit. It recognized the importance of the issue of missing children raised by by NGO Bachpan Bachao Andolan through senior advocate H S Phoolka and said, "This is high time the issue is given top-most priority by the central government, all state governments and all other government and non-government actors/stakeholders."

The commission said it had constituted a committee after the Nithari serial rape-cum-murders to address the issue of missing children. The committee had issued guidelines and sent it to all states.

"But what happens to most of the recommendations, guidelines and reports has happened to the guidelines sent by the commission. The status remains the same, the guidelines became part of record, some states have simply filled up the form and sent back to the commission, while rest still have to find time to complete the paper formality," the NHRC said.

Taking note of Phoolka's allegation that nearly 200 children went missing every day from various states and 100 remained untraceable, the bench said, "Still no one seems to be bothered about it." It listed the matter for detailed hearing on April 15.

On March 17 last year, the court had issued notices to the Centre and states on the NGO's PIL seeking an advanced scientific mechanism to investigate and recover missing children. "In India, in the period from January 2008 to January 2010, over 1.17 lakh children have gone missing in 392 districts in India. Out of them, 41,546 are still untraced," it had said.

The petitioner had sought a direction to the Union government to formulate a National Action Plan on the issue of missing children which should include investigation, recovery, counseling and standard operating procedures for law enforcing agencies on coordinating their efforts.

dhananjay.mahapatra@timesgroup.com

Read More..

Hip implants a bit more likely to fail in women

CHICAGO (AP) — Hip replacements are slightly more likely to fail in women than in men, according to one of the largest studies of its kind in U.S. patients. The risk of the implants failing is low, but women were 29 percent more likely than men to need a repeat surgery within the first three years.

The message for women considering hip replacement surgery remains unclear. It's not known which models of hip implants perform best in women, even though women make up the majority of the more than 400,000 Americans who have full or partial hip replacements each year to ease the pain and loss of mobility caused by arthritis or injuries.

"This is the first step in what has to be a much longer-term research strategy to figure out why women have worse experiences," said Diana Zuckerman, president of the nonprofit National Research Center for Women & Families. "Research in this area could save billions of dollars" and prevent patients from experiencing the pain and inconvenience of surgeries to fix hip implants that go wrong.

Researchers looked at more than 35,000 surgeries at 46 hospitals in the Kaiser Permanente health system. The research, published Monday in JAMA Internal Medicine, was funded by the U.S. Food and Drug Administration.

After an average of three years, 2.3 percent of the women and 1.9 percent of the men had undergone revision surgery to fix a problem with the original hip replacement. Problems included instability, infection, broken bones and loosening.

"There is an increased risk of failure in women compared to men," said lead author Maria Inacio, an epidemiologist at Southern California Permanente Medical Group in San Diego. "This is still a very small number of failures."

Women tend to have smaller joints and bones than men, and so they tend to need smaller artificial hips. Devices with smaller femoral heads — the ball-shaped part of the ball-and-socket joint in an artificial hip — are more likely to dislocate and require a surgical repair.

That explained some, but not all, of the difference between women and men in the study. It's not clear what else may have contributed to the gap. Co-author Dr. Monti Khatod, an orthopedic surgeon in Los Angeles, speculated that one factor may be a greater loss of bone density in women.

The failure of metal-on-metal hips was almost twice as high for women than in men. The once-popular models were promoted by manufacturers as being more durable than standard plastic or ceramic joints, but several high-profile recalls have led to a decrease in their use in recent years.

"Don't be fooled by hype about a new hip product," said Zuckerman, who wrote an accompanying commentary in the medical journal. "I would not choose the latest, greatest hip implant if I were a woman patient. ... At least if it's been for sale for a few years, there's more evidence for how well it's working."

___

Online:

Journal: http://www.jamainternalmed.com

Read More..

Nike, Oakley Distance Themselves from Pistorius

Corporate sponsors of Olympic "blade runner" Oscar Pistorius have begun to distance themselves from the sprinter, who is accused of murdering his model girlfriend, Reeva Steenkamp. Pistorius is back to court in South Africa Tuesday morning on murder charges.

Oakley, the eyewear manufacturer, and the sporting goods giant Nike announced today that they would no longer run ads featuring Pistorius, the South African double-amputee who gained worldwide fame for running on carbon-fiber blades.

"In light of the recent allegations, Oakley is suspending its contract with Oscar Pistorius, effective immediately. Our hearts are with the families during this difficult time and we'll continue to follow the developments in this tragic case," Oakley spokeswoman Cheri Quigley said in a statement released this afternoon.

Earlier in the day, Nike said it had "no plans" to use Pistorius in future ad campaigns, according to the Associated Press. Nike had already pulled an Internet ad showing Pistorius starting to sprint with the caption, "I am the bullet in the chamber."

The companies made their announcements shortly after Pistorius' own agent, Peet Van Zyl, said publicly that he expected the sponsors to stick with Pistorius through the legal process.

PHOTOS: Paralympic Champion Charged in Killing

Pistorius will appear in court Tuesday morning for a bail hearing. His attorneys are expected to argue against the charge of premeditated murder.

His family has said the shooting was an accident.

The news comes as more details emerge about the incident on Thursday morning in which Pistorius allegedly shot and killed Steenkamp at his gated home in Pretoria, South Africa.

Bryn Lennon; Gallo Images/Getty Images

Oscar Pistorius: Possibly Incriminating Information Leaked Watch Video

'Blade Runner' Murder Charges: Family Insist Accidental Shooting Watch Video

'Blade Runner' Murder Mystery: Family Speaks Out Watch Video

News reports in local papers have said that police are investigating whether Pistorius had an anger-management problem that led to the incident. They focused in on a bloodied cricket bat that may have been used when Steenkamp died.

A "shocked" teammate of Oscar Pistorius rebutted the rumors and speculation in South Africa that Pistorius had an anger problem.

Ofentse Mogawane, a sprinter for the South African Olympic team who ran the 400-meter relay with Pistorius in the London summer games last year, said Pistorius had always been genial to him and other people.

Mogawane said he would be in court Tuesday to support his friend.

"Basically, he was a very good guy to us, to the teammates and to most athletes," Mogawane said. "He was a really humble person and I wouldn't say a bad word about him. We never had any kind of clash, never any kind of fight or disagreement or arguing.

"The way Oscar's case was, it shocked me, shocked most of the people who know him. Tomorrow in court I am going to be there to support him. To hear what happened the night of the incident," he said.

"Sometimes when people are angry they cannot control their anger. Something must have happened."

Mogawane, 30, spoke in support of Pistorius after a report in South Africa's City Press newspaper that claimed police were looking into the possibility that a bloody cricket bat found in his bedroom was used before the shooting.

"The way the news has been running around in South Africa, that he is a short-tempered person, a person who has problems with anger management, they just want something to say," Mogawane said. "They don't know Oscar at all. They just want to get interviewed and take pictures. But truly speaking, it's just a lot of speculation."

Mogawane said he had seen Pistorius become angry before, but only in the same way as any other athlete or person.

But the City Press reported Sunday that police are investigating different scenarios involving the bat. Among them is the possibility that the flat-fronted bat was used in a violent argument before the shooting.

The paper also reported that Pistorius might have first shot Steenkamp in the bedroom, and that she possibly fled to the bathroom where she was shot three more times through the door.

When Pistorius' family arrived at the scene before paramedics, they saw him carrying Steenkamp down the stairs and performing mouth-to-mouth resuscitation on her, City Press reported.

Pistorius, who is nicknamed the "blade runner" because of the carbon-fiber blades on which he runs, has canceled all his upcoming racing appearances, his agent said Sunday night.

The decision was made to "allow Oscar to concentrate on the upcoming legal proceedings and to help and support all those involved as they try to come to terms with this very difficult and distressing situation," Van Zyl, of In Site Athlete Management, said in a statement.

Pistorius' father was quoted overnight in the South African paper The Sunday Times saying his countrymen are destroying a national icon.

Read More..

Time to refer Syrian war crimes to ICC: U.N. inquiry

GENEVA (Reuters) - United Nations investigators said on Monday that Syrian leaders they had identified as suspected war criminals should face the International Criminal Court (ICC).

The investigators urged the U.N. Security Council to "act urgently to ensure accountability" for violations, including murder and torture, committed by both sides in an uprising and civil war that has killed about 70,000 people since March 2011.

"Now really it's time ... We have a permanent court, the International Criminal Court, who would be ready to take this case," Carla del Ponte, a former ICC chief prosecutor who joined the U.N. team in September, told a news briefing in Geneva.

But because Syria is not party to the Rome Statute that established the ICC, the only way the court can investigate the situation is if it receives a referral from the Security Council. Russia, Assad's long-standing ally and a permanent veto-wielding member of the council, has opposed such a move.

"We cannot decide. But we pressure the international community to decide because it's time to act," del Ponte said.

Brazilian expert Paulo Pinheiro, who leads the U.N. inquiry set up in 2011, said: "We are in very close dialogue with all the five permanent members and with all the members of the Security Council, but we don't have the key that will open the path to cooperation inside the Security Council."

His team of some two dozen experts is tracing the chain of command in Syria to establish criminal responsibility and build a case for eventual prosecution.

"Of course we were able to identify high-level perpetrators," del Ponte said, adding that these were people "in command responsibility...deciding, organizing, planning and aiding and abetting the commission of crimes".

She said it was urgent for the Hague-based war crimes tribunal to take up cases of "very high officials", but did not identify them, in line with the inquiry's practice.

"We have crimes committed against children, rape and sexual violence. We have grave concerns. That is also one reason why an international body of justice must act because it is terrible."

Del Ponte, who tried former Yugoslav President Slobodan Milosevic at the International Criminal Tribunal for the Former Yugoslavia on war crimes charges, said the ICC prosecutor would need to deepen the investigation on Syria before an indictment could be prepared.

Karen Koning AbuZayd, an American member of the U.N. team, told Reuters it had information pointing to "people who have given instructions and are responsible for government policy, people who are in the leadership of the military, for example".

The inquiry's third roster of suspects, building on lists drawn up in the past year, remains secret. It will be entrusted to U.N. High Commissioner for Human Rights Navi Pillay upon expiry of its mandate at the end of March, the report said.

Pillay, a former ICC judge, said on Saturday Assad should be investigated for war crimes, and called for outside action on Syria, including possible military intervention.

Pinheiro said the investigators would not speak publicly about "numbers, names or levels" of suspects.

SEVEN MASSACRES IDENTIFIED

The investigators' latest report, covering the six months to mid-January, was based on 445 interviews conducted abroad with victims and witnesses, as they have not been allowed into Syria.

"We identified seven massacres during the period, five on the government side, two on the armed opponents' side. We need to enter the sites to be able to confirm elements of proof that we have," del Ponte said.

The U.N. report said the ICC was the appropriate institution for the fight against impunity in Syria. "As an established, broadly supported structure, it could immediately initiate investigations against authors of serious crimes in Syria."

Government forces have carried out shelling and air strikes across Syria including Aleppo, Damascus, Deraa, Homs and Idlib, the 131-page report said, citing corroborating satellite images.

"Government forces and affiliated militias have committed extra-judicial executions, breaching international human rights law. This conduct also constitutes the war crime of murder. Where murder was committed as part of a widespread or systematic attack against a civilian population, with knowledge of that attack, it is a crime against humanity," the report said.

Those forces have targeted bakery queues and funeral processions to spread "terror among the civilian population".

Rebels fighting to topple Assad have also committed war crimes including murder, torture, hostage-taking and using children under age 15 in hostilities, the U.N. report said.

"They continue to endanger the civilian population by positioning military objectives inside civilian areas" and rebel snipers had caused "considerable civilian casualties", it said.

George Sabra, a vice president of the opposition Syrian National Coalition, asked about the U.N. report, told Reuters at a conference in Stockholm: "We condemn all kind of crimes, regardless who did it.

"We can't ignore that some mistakes have been made and maybe still happen right now. But nobody also can ignore that the most criminal file is that of the regime."

(This story has been corrected to fix name of Milosevic tribunal in 11th paragraph)

(Reporting by Stephanie Nebehay; additional reporting by Anna Ringstrom in Stockholm; Editing by Mark Heinrich)

Read More..

Greater US military role in Mali likely after polls: senator

BAMAKO: The United States is likely to play a more active military role in Mali, where French-led forces are battling Islamist rebels, after the country holds elections, the chair of a key Senate sub-committee said Monday.

Washington has been providing intelligence, transport and mid-air refuelling to France, which launched its intervention last month, but cannot work directly with the Malian army until a democratically elected government replaces current leaders who came to power after a coup, said Christopher Coons, chair of the Senate foreign relations committee's Africa sub-committee.

"There is the hope that there will be additional support from the United States in these and other areas, but ... American law prohibits direct assistance to the Malian military following the coup," Coons told journalists in the Malian capital.

"After there is a full restoration of democracy, I would think it is likely that we will renew our direct support for the Malian military," added the senator, who led a bipartisan congressional delegation to Mali to meet with interim president Dioncounda Traore and French and African defence officials.

US military aid to Mali before the March 2012 coup consisted largely of training and equipment such as vehicles, a State Department official said.

But military assistance "would obviously be resumed in a way commensurate with the current needs. Priorities would have shifted a bit," the official added.

"There could be other kinds of assistance that had there not been a coup we could have provided, or requests for things now that we can't provide."

Some US lawmakers criticised President Barack Obama's administration last week for not doing more to help France in Mali.

"This is a NATO ally fighting Al-Qaeda-linked terrorists -- it shouldn't be that hard," said House foreign affairs committee chairman Ed Royce.

The hint of greater US involvement after elections adds to the complicated calculus of picking a date for the polls.

Traore, the interim president, has said he wants elections by July 31.

But critics say that is too soon given the problems Mali still faces, including ongoing insurgent attacks, a deeply divided military and hundreds of thousands of people who have fled their homes.

The minister responsible for organising the elections, Territorial Administration Minister Moussa Sinko Coulibaly, said last week the timeline "can be changed if necessary".

France, which launched its intervention on January 11 as Al-Qaeda-linked groups that had occupied the north for 10 months made incursions into government territory, is keen to share the military burden in Mali, and has announced plans to start bringing its 4,000 troops home in March.

The European Union formally approved a military training mission Monday that will be tasked with getting Mali's under-funded army ready to secure reclaimed territory.

But France is the only Western country with combat troops on the ground, and would like to hand over to some 6,000 west African troops who are slowly being deployed to help.

Mali imploded after a coup by soldiers who blamed the government for the army's humiliation at the hands of separatist rebels in the north.

With the capital in disarray, Al-Qaeda-linked fighters hijacked the independence rebellion and took control of a territory larger than Texas.

-AFP/ac

Read More..

Wait of Rajiv killer's mother continues

CHENNAI: A shiver runs down her spine every time 66-year-old Arputham Ammal recalls the hanging of Afzal Guru, convicted for the Parliament attack. Her son Perarivalan, one of the three convicts on death row in Vellore prison for his role in the Rajiv Gandhi assassination, is awaiting a verdict from the Supreme Court as his mercy plea was rejected by President Pranab Mukherjee. The case is now pending for a different reason — the 11-year delay in execution.

The fact that the letter informing Guru's wife about the hanging, sent by speed post, was delayed, is stuck in her mind. "I dread the morning news flashes or seeing the postman on the street," she said. When she met her son last Thursday, Perarivalan talked about Guru's hanging.

A badge pinned on her sari that reads 'Marana Thandanai Ozhipom' (abolish capital punishment) says everything she feels about the death penalty. It's a badge she has decided to wear for the rest of her life. Ammal said she and her family are wedded to the ideals of Periyar and Dravida Kazhagam.

"He (Perarivalan) was 19 when he was arrested, now he is 41. All I can do is meet him in prison and talk. I have done that for the last 22 years and he gives me courage during my visits," said Ammal, who finished her SSLC in 1963. Ammal, 66, lives with her grandson in Chennai, while her 76-year-old husband Kuyil Dasan aka Gnanasekaran, a Tamil poet, stays with one of her two daughters.

"Arivu (as she calls her son) and I us used to sing together," she said, recalling the days when her son was free. "He sings better than me, especially the melodies of Ilayaraja. I like the older MGR songs," says Ammal. She has a reason to like MGR songs. "His movies and songs were about people and their lives. Unlike others, his songs had a substance of life, and those lyrics had something we could easily relate to," she said.

"He (Arivu) was an avid reader since school. Other than reading history, he enjoyed Bharathiyar and Bharathidasan poems. He continues to maintain the habit of reading and discusses about the latest novels and poems published in Tamil when we meet," she said.

Whenever she meets her son, she takes a bundle of books he's asked for, mostly international history, poems and novels. "We never gave him any luxury in life. Following Periyar's ideology, we lived a simple life. Throughout his school days, he was the best student and passed his higher secondary examination with distinction," she said. "Everyone likes him. Even the retired jail officers have great regard for him. I hope I can live with him before I die."

Read More..